Well maybe that's a slight exaggeration. There are still things to see along the interstates: usually the rolling plains or steep mountain overlooks. But certainly no rattlesnake museum or Indian trading posts.
For all the good interstates have done, their creation was all but a death knell for the scenic Sunday drive, US 66 and many small businesses along the old 2-Lane who were unable to adapt.
I still prefer the old 2-Lane when I have the time, but if I'm in a hurry, I'll take the interstate.
(yes, I know: there is NO I-54 and Interstates never used the square font. Call it creative license ;) )